No Hard Hearts
The Pharisees had a heart condition that grieved Jesus. Their hearts were hard and insensitive. If you'll look in Mark 3, you'll see what I'm talking about.
God was right there in their midst, and they, of all people, should have realized it. They knew the Scriptures backward and forward, and Jesus fit every messianic prophecy written there. But the insensitivity of their hearts literally blinded them to who He was.
The hearts of the Pharisees were also hardened to the needs of the people around them.
That very same thing is still happening today.